Figure 2.

Volumetric MRI

Boxplots of standardised residuals (covariate adjusted) for volumes of (A) putamen, (B) caudate, (C) whole brain, (D) grey matter, (E) white matter, and (F) ventricles corrected for intracranial volume. Horizontal lines are the medians, boxes are upper and lower quartiles, and whiskers are 1·5 × IQR. Putamen volume was significantly reduced in individuals with preHD compared with controls (FDR=0·03). None of the other brain measures showed significant between-group differences. FDR=false discovery rate correction. PreHD=premanifest Huntington's disease.