Figure 1.

(A) Maximal intensity projections of anti-programmed cell death protein-1 plus anti-cytotoxic T-lymphocyte antigen-4 treated or vehicle CT26 tumor-bearing mice demonstrating tumor uptake and clearance of the GZP positron emission tomography (PET) imaging agent. (B) Average target-to-background (TBR) (n=4) of treated and vehicle CT26 tumor-bearing mice on days 6, 9 and 12 post-tumor inoculation, where error bars denote SE measurements (SEM). (C) Parametric linear correlation of released granzyme as denoted by GZP PET TBR compared with intracellular granzyme B detected by flow cytometry. The same analyzes were performed in MC38 tumors (D–F). *P<0.05.