Table 4.
Complement levels in subjects with intermediate AMD stratified by the presence or absence of RPD
| Complement factors Median (IQR) |
RPD (n=39) |
No RPD (n=70) |
OR (95% CI)* | P value† |
| C1q (µg/mL) | 79 (68–94) | 76 (67–88) | 1.02 (0.99 to 1.04) | 0.40 |
| C4 (µg/mL) | 108 (99–117) | 105 (98–120) | 0.99 (0.98 to 1.02) | 0.92 |
| C2 (µg/mL) | 5.2 (4.1–5.9) | 4.2 (3.2–5.1) | 1.32 (1.07 to 1.66) | 0.21 |
| MBL (ng/mL) | 714 (295–1110) | 860 (274–1458) | 1.00 (0.99 to 1.00) | 0.90 |
| C4b (µg/mL) | 10 (9–12) | 10 (9–11) | 1.03 (0.87 to 1.22) | 0.90 |
| C3 (µg/mL) | 81 (68–92) | 76 (62–94) | 0.99 (0.98 to 1.01) | 0.90 |
| Factor B (µg/mL) | 109 (99–123) | 112 (100–128) | 1.00 (0.98 to 1.01) | 0.90 |
| Factor D (µg/mL) | 1.8 (1.4–2.6) | 1.6 (1.4–2.1) | 1.16 (0.96 to 1.43) | 0.40 |
| Properdin (µg/mL) | 19 (17–23) | 19 (18–23) | 0.96 (0.85 to 1.07) | 0.90 |
| C3a (ng/mL) | 66 (55–77) | 60 (49–74) | 1.00 (0.98 to 1.01) | 0.90 |
| iC3b/C3b (ng/mL) | 653 (585–834) | 655 (525–861) | 1.00‡ (0.99 to 1.02) | 0.90 |
| Ba (ng/mL) | 704 (564–909) | 722 (624–851) | 1.00‡ (0.98 to 1.02) | 0.92 |
| Factor H (µg/mL) | 199 (181–220) | 196 (174–228) | 1.00 (0.99 to 1.01) | 0.92 |
| Factor I (µg/mL) | 27 (24–30) | 25 (22–29) | 1.06 (0.99 to 1.15) | 0.40 |
| C5 (µg/mL) | 40 (35–47) | 38 (33–42) | 1.03 (0.99 to 1.08) | 0.40 |
| C5a (pg/mL) | 732 (613–866) | 663 (564–761) | 1.02‡ (1.00 to 1.05) | 0.40 |
| SC5b-9 (ng/mL) | 179 (161–218) | 188 (155–213) | 1.02‡ (0.93 to 1.11) | 0.90 |
*OR from the univariate logistic regression with 95% CIs.
†P values obtained from univariate logistic regression and adjusted for multiple comparisons using FDR.
‡OR corresponding to change in 10 units of complement factor.
AMD, age-related macular degeneration; RPD, reticular pseudodrusen.