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. 2020 Apr 8;8(1):e000213. doi: 10.1136/jitc-2019-000213

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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hEGFRvIII:CD3 bi-scFv binds only human CD3-expressing cells. (A) hEGFRvIII:CD3 bi-scFv binding to PBMCs from human, cynomolgus, beagle, mouse, pig, rabbit, and rat were tested using flow cytometry. Binding studies using only the secondary detection PEPvIII multimer served as control. (B) hEGFRvIII:CD3 bi-scFv binding to PBMCs from three human donors. Dashed line shows EC₂₀. EC₂₀, 20% of the maximal effective concentration; EGFRvIII, epidermal growth factor receptor variant III; PBMCs, peripheral blood mononuclear cells.