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hEGFRvIII:CD3 bi-scFv extends survival in vivo. Immunodeficient NSG mice were coimplanted with U87-MG-EGFRvIII and human PBMCs. Subsequently, mice in the treatment group received 50 µg hEGFRvIII:CD3 bi-scFv daily for 5 days via intravenous tail injection. Bar indicates time of hEGFRvIII:CD3 bi-scFv treatment. EGFRvIII, epidermal growth factor receptor variant III; NSG, NOD-scid gamma; PBMCs, peripheral blood mononuclear cells.
