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. 2020 May 26;8(1):e000375. doi: 10.1136/jitc-2019-000375

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Prognosis according to the neoantigen load, HLA-class I expression or both in patients with HR-proficient or HR-deficient tumors. Kaplan-Meier PFS and OS of 46 HR-proficient HGSC patients stratified according to neoAg number (A), HLA-class I expression (B), and the combination of both neoAg load and HLA expression (C). Kaplan-Meier PFS and OS of 34 HR-deficient HGSC patients stratified according to neoAg number (D), HLA-class I expression (E), and both (F). Low, high designates values below or above the median. Statistical analysis was by log-rank testing. HGSC, high-grade serous ovarian carcinoma; HLA, human leukocyte antigen; HR, homologous recombination; NS, not significant; OS, overall survival; PFS, progression-free survival.