Fig. 1.
Diagrammatic overview of the multistate model for ferroptosis. Input parameters are model elements that do not change during the course of the simulation (blue outline; dashed line beneath), model variables on the other hand will change concentrations until reaching a steady state (blue outline). Molecular species that are implicitly included in the model but not simulated are also shown (black outline) as well as ferroptosis inducers (green outline). AA: arachidonic acid, LH-P: phospholipid conjugated to polyunsaturated fatty acid, LIP: labile iron pool, LOOH: lipid hydroperoxide, LO•: peroxide radical, LOH: redox-inert alcohol, MUFA: monounsaturated fatty acids, PL: phospholipid, PUFA-CoA: acetylated polyunsaturated fatty acids, ROS: reactive oxygen species, system xc−: cystine/glutamate transporter, SFA: saturated fatty acids.