Fig. 2.

Addition of erastin or RSL3 in the baseline model stimulates a ferroptotic response. Steady state values of baseline model variables are shown (a) without and (b) with addition of the ferroptosis-inducers erastin or RSL3. Note that only SLC7A11 responds differently to erastin (no change) vs. RSL3 (lowered). Variables in gray (‘Input’) are external, and thus are set at time t = 0 and stay constant throughout the course of the simulations. The remainder of the variables are classified by types of molecular species or mode of action.