Table 2.
In vitro cytotoxicity activity (IC50 values, µM) of dicyanomethylene squaraine dyes 1–5 against Caco-2 and HepG2 cells exposed to different irradiation times (0, 7 and 14 min) and different incubation periods with the irradiated dyes (1 and 24 h).
| Dye | Irradiation Time (min) | Caco-2 | HepG2 | ||
|---|---|---|---|---|---|
| 1 h | 24 h | 1 h | 24 h | ||
| 1 | 0 | >5 | >5 | >5 | >5 |
| 7 | 0.173 | 0.536 | 0.285 | 0.241 | |
| 14 | 0.563 | 0.244 | 0.259 | 0.263 | |
| 2 | 0 | >5 | >5 | >5 | >5 |
| 7 | >5 | >5 | >5 | >5 | |
| 14 | 2.520 | 1.426 | 1.432 | 1.016 | |
| 3 | 0 | >5 | >5 | >5 | >5 |
| 7 | >5 | 0.983 | 3.661 | 0.768 | |
| 14 | 1.306 | 0.345 | 0.116 | 0.155 | |
| 4 | 0 | >5 | >5 | >5 | >5 |
| 7 | >5 | >5 | >5 | >5 | |
| 14 | >5 | 2.943 | >5 | 4.935 | |
| 5 | 0 | >5 | >5 | >5 | >5 |
| 7 | 0.193 | 0.094 | 0.263 | 0.188 | |
| 14 | 0.079 | 0.032 | 0.143 | 0.108 | |