Table 4.
Clinical data of the acute pancreatitis patient cohort based on H/L ratio
| Parameters | H/L ratio < 0.465 (n = 86) | H/L ratio > 0.465 (n = 80) | P |
|---|---|---|---|
| Demographic Data | |||
| Age, mean (SD),y | 45.71 (13.67) | 49.18 (16.20) | 0.141 |
| Male, n (%) | 45 (52.33) | 52 (65.00) | 0.098 |
| Etiology, n (%) | 0.031 | ||
| Biliary | 36 (41.86) | 35 (43.80) | |
| Hyperlipidemia | 24 (27.91) | 10 (12.50) | |
| Others | 26 (30.23) | 35 (43.80) | |
| Underlying medical conditions | |||
| Hypertension, n (%) | 6 (6.97) | 18 (22.50) | 0.004 |
| Diabetes Mellitus, n (%) | 14 (16.28) | 14 (17.50) | 0.834 |
| Severity, n (%) | 0.034 | ||
| Moderately severe | 19 (22.09) | 8 (10.00) | |
| Severe | 67 (77.91) | 72 (90.00) | |
| APACHEIIScore*, mean (SD) | 17.99 (6.50) | 20.50 (7.85) | 0.027 |
| Ranson’s Score*, mean (SD) | 4.18 (1.46) | 4.30 (1.64) | 0.635 |
| CHOL, mean (SD), mmol/L | 3.63 (2.61) | 3.20 (2.96) | 0.323 |
| HDL-C, mean (SD), mmol/L | 0.33 (0.17) | 0.44 (0.36) | 0.015 |
| LDL-C, mean (SD), mmol/L | 1.25 (0.72) | 0.59 (0.51) | < 0.001 |
| H/L ratio, mean (SD) | 0.28 (0.09) | 1.14 (1.15) | < 0.001 |
| Ventilation free days#, mean (SD), d | 16.13 (9.16) | 17.57 (8.71) | 0.045 |
| Renal replacement therapy, n (%) | 6 (6.97) | 21 (26.25) | 0.001 |
| ICU LOS, mean (SD), d | 25.86 (26.62) | 21.02 (17.43) | 0.163 |
| Hospital LOS, mean (SD), d | 33.40 (22.88) | 27.85 (23.50) | 0.126 |
| Complete blood count* | |||
| RBC, mean (SD),× 109/L | 3.15 (0.69) | 3.21 (1.00) | 0.649 |
| HGB, mean (SD), g/L | 95.34 (22.37) | 95.12 (27.54) | 0.955 |
| HCT, mean (SD), L/L | 0.29 (0.06) | 0.29 (0.08) | 0.844 |
| PLT, mean (SD),×109/L | 156.36 (104.59) | 144.06 (111.11) | 0.463 |
| WBC, mean (SD),×109/L | 11.95 (5.18) | 12.74 (6.52) | 0.389 |
| Coagulation test* | |||
| APTT, mean (SD), s | 36.57 (10.40) | 44.76 (19.51) | 0.001 |
| Fib, mean (SD), g/L | 5.07 (1.90) | 4.13 (1.77) | 0.001 |
| TT, mean (SD), s | 19.52 (12.51) | 18.05 (2.65) | 0.290 |
| Arterial Blood Gas Test* | |||
| pH, mean (SD) | 7.36 (0.27) | 7.28 (0.46) | 0.193 |
| PaO2, mean (SD), mmHg | 84.18 (29.66) | 95.73 (41.32) | 0.045 |
| PaCO2, mean (SD), mmHg | 40.25 (6.77) | 39.50 (9.84) | 0.573 |
| Lac, mean (SD), mmol/L | 1.63 (0.49) | 1.96 (1.02) | 0.012 |
| Biochemical analysis* | |||
| PCT, mean (SD), ng/mL | 6.82 (16.18) | 10.44 (17.42) | 0.184 |
| CRP, mean (SD), mg/L | 189.16 (105.01) | 183.75 (92.43) | 0.747 |
| IL-6, mean (SD), ng/mL | 287.52 (481.42) | 459.90 (752.33) | 0.114 |
| Serum sodium, mean (SD), mmol/L | 137.66 (6.60) | 140.05 (7.72) | 0.035 |
| Serum potassium, mean (SD), mmol/L | 3.75 (0.41) | 3.81 (0.50) | 0.368 |
| Serum chloride, mean (SD), mmol/L | 108.05 (6.33) | 109.45 (6.95) | 0.181 |
| TB, mean (SD), mmol/L | 40.29 (57.13) | 41.17 (53.33) | 0.918 |
| DB, mean (SD), mmol/L | 30.97 (47.86) | 33.20 (46.99) | 0.763 |
| ALT, mean (SD), mmol/L | 50.06 (167.93) | 92.73 (199.87) | 0.140 |
| AST, mean (SD), mmol/L | 78.55 (228.91) | 164.60 (465.49) | 0.137 |
| ALB, mean (SD), mmol/L | 30.74 (5.11) | 29.41 (6.21) | 0.135 |
| Glu, mean (SD), mmol/L | 10.07 (3.11) | 10.06 (3.72) | 0.982 |
| Crea, mean (SD), mmol/L | 141.64 (140.04) | 212.41 (196.63) | 0.009 |
| Cys-c, mean (SD), mmol/L | 1.43 (0.83) | 1.93 (1.35) | 0.005 |
| GGT, mean (SD), mmol/L | 108.49 (123.97) | 91.62 (108.70) | 0.352 |
| TG, mean (SD), mmol/L | 3.56 (2.26) | 4.07 (5.21) | 0.419 |
APACHE Acute Physiology and Chronic Health Evaluation, RBC Red blood cell, HGB Hemoglobin, HCT Hematocrit, MCV Mean corpuscular volume, MCH Mean corpuscular hemoglobin, MCHC Mean corpuscular hemoglobin concentration, RDW Red blood cell distribution width, PLT Platelets, WBC white blood cell, INR International normalized ratio, PT prothrombin time, APTT Activated partial thromboplastin time, Fib fibrinogen, TT Thrombin time, PaO2 Arterial oxygen partial pressure, PaCO2 Arterial carbon dioxide partial pressure, BE Base excess, Lac lactate, PCT Procalcitonin, TB Total bilirubin, DB Direct bilirubin, ALT Alanine Aminotransferase, AST Aspartate Aminotransferase, ALP Alkaline Phosphatase, TP Total protein, ALB Albumin, Glu Glucose, Crea Creatinine, Cys-c Cystatin C, GGT Gamma-Glutamyl Transferase, TG Triglycerides, CHOL cholesterol, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol, H/L HDL-C/ LDL-C, LOS length of stay, IQR interquartile range