Table 1.
Comparison of clinical characteristics between the exposed group with CMV disease and the matched unexposed group without CMV diseases
| Characteristics | CMV diseases | P-value | |
|---|---|---|---|
| No | Yes | ||
| (n = 3435) | (n = 687) | ||
| Sex, male | 1950 (56.77) | 390 (56.77) | > 0.999 |
| Age, years | 57.98 ± 11.41 | 57.98 ± 11.42 | > 0.999 |
| ≥ 60 years | 1405 (40.9) | 281 (40.9) | > 0.999 |
| Duration of total follow-up, years | 4.10 ± 1.58 | 3.73 ± 1.80 | < 0.001 |
| Low income statusa | 824 (23.99) | 181 (26.35) | 0.189 |
| BMI, kg/m2 | 23.39 ± 5.95 | 22.63 ± 6.72 | 0.318 |
| ≥ 25 kg/m2 | 832 (24.22) | 163 (23.73) | 0.294 |
| Co-morbid diseases, yesb | 192 (5.59) | 258 (37.55) | < 0.001 |
| Solid organ transplant recipients | 30 (0.87) | 146 (21.25) | < 0.001 |
| Kidney | 27 (0.79) | 109 (15.87) | < 0.001 |
| Liver | 3 (0.09) | 19 (2.77) | < 0.001 |
| Heart | 0 (0) | 13 (1.89) | – |
| Lung | 0 (0) | 5 (0.73) | – |
| HSCT recipients | 16 (0.47) | 95 (13.83) | < 0.001 |
| Malignant neoplasmsc | 113 (3.29) | 69 (10.04) | < 0.001 |
| End-stage renal disease on dialysis | 92 (2.68) | 35 (5.09) | < 0.001 |
| NIDDM | 386 (11.24) | 205 (29.84) | < 0.001 |
| Hypertension | 974 (28.36) | 328 (47.74) | < 0.001 |
| Dyslipidaemia | 607 (17.67) | 201 (29.26) | < 0.001 |
| Moderate-to-severe dementia | |||
| All | 105 (3.06) | 38 (5.53) | 0.001 |
| Alzheimer’s | 77 (2.24) | 23 (3.35) | 0.085 |
| Vascular | 12 (0.35) | 7 (1.02) | 0.018 |
| Other | 16 (0.47) | 8 (1.16) | 0.028 |
Data are expressed as number (percentage) and median ± standard deviation
Abbreviations: BMI body mass index, CMV cytomegalovirus, ESRD end-stage renal disease, HSCT haematopoietic stem cell transplantation, NIDDM non-insulin-dependent diabetes mellitus, SOT solid organ transplantation
aLower 25th percentile of socioeconomic status
bPatients with ≥ one among co-morbid diseases of SOT recipients, HSCT recipients, malignant neoplasms, and ESRD on dialysis
cIncluding haematologic malignancies and excluding in situ neoplasms