Table 2.
Multivariate logistic regression analyses to examine the effect of cytomegalovirus diseases on the development of moderate-to-severe dementia
| Type of dementia | CMV diseases | Number of participants | Events | Total follow-up duration (person-years) | IRa | OR (95% CI) | ||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||||
| All | No | 3435 | 105 | 14,083 | 7.46 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
| Yes | 687 | 38 | 2564 | 14.82 | 1.99 (1.37–2.88) | 2.07 (1.42–3.03) | 1.88 (1.23–2.82) | |
| AD | No | 3435 | 77 | 14,083 | 5.47 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
| Yes | 687 | 23 | 2564 | 8.97 | 1.65 (1.04–2.63) | 1.69 (1.04–2.75) | 1.62 (1.01–2.64) | |
| VaD | No | 3435 | 12 | 14,083 | 0.85 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
| Yes | 687 | 7 | 2564 | 2.73 | 3.14 (1.24–7.98) | 3.30 (1.28–8.40) | 2.87 (1.08–7.45) | |
| Others | No | 3435 | 16 | 14,083 | 1.14 | 1 (Ref.) | 1 (Ref.) | 1 (Ref.) |
| Yes | 687 | 8 | 2564 | 3.12 | 2.71 (1.16–6.34) | 2.81 (1.89–6.65) | 2.69 (1.07–6.43) | |
Data are expressed as number or OR (95% CI). Events indicate the new-onset moderate-to-severe dementia. Model 1, non-adjusted; Model 2, age-, sex-, low income status, and BMI-adjusted; Model 3, age-, sex-, low income status-, BMI-, SOT recipients-, HSCT recipients-, malignant neoplasms-, ESRD on dialysis-, NIDDM-, hypertension-, and dyslipidaemia-adjusted
Abbreviations: AD Alzheimer’s disease, BMI body mass index, CI confidence interval, CMV cytomegalovirus, ESRD end-stage renal disease, HSCT haematopoietic stem cell transplantation, IR incidence rate, NIDDM non-insulin-dependent diabetes mellitus, No., number of patients, OR odds ratio, Ref. reference, SOT solid organ transplantation, VaD vascular dementia
aPer 1000 person-years