Table 5.
Composite weights of the Alzheimer’s Prevention Initiative Preclinical Cognitive Composite (APCC)
| Domain | Test item | Weight | Maximum possible | Weighted maximum |
|---|---|---|---|---|
| Perceptual Speed/Working Memory | Symbol Digit Modalities‡ | 0.26 | 110 | 28.6 |
| Orientation | MMSE Orientation to Time‡ | 2.24 | 5 | 11.2 |
| MMSE Orientation to Place | 2.14 | 5 | 10.7 | |
| Episodic Memory | Logical Memory Delayed‡ | 0.53 | 25 | 13.2 |
| Word List Memory Delayed | 1.36 | 10 | 13.6 | |
| Visual Spatial | Judgment of Line Orientation | 0.68 | 15 | 10.2 |
| Raven’s Progressive Matrices (subset of 9 items from A and B)‡ | 1.39 | 9 | 12.5* | |
| Total Score (sum of weighted maximums) | 100 | |||
MMSE Mini-Mental State Examination
‡Item included in original, late-onset AD composite cognitive test score (this composite consisted of Category Fluency [fruits and vegetables], Boston Naming Test [15 items], Logical Memory Delayed Recall, East Boston Naming Test Immediate Recall, Raven’s Progressive Matrices Subset, Symbol Digit Modalities and MMSE Orientation to Time [12])
*Rounded to the nearest 0.1