Table 3. Ranges of cSAR(X) Values for Substituents for Adenine and Purine C8–X- and C2–X-Substituted Tautomers^a.

cSAR(X)
	C8–X		C2–X
	AD	PU	AD	PU
NO2	0.061	0.036	0.044	0.045
CN	0.048	0.021	0.034	0.028
CHO	0.054	0.025	0.036	0.032
Cl	0.056	0.031	0.058	0.053
F	0.041	0.022	0.042	0.037
H	0.039	0.019	0.032	0.028
Me	0.050	0.027	0.049	0.045
OMe	0.066	0.026	0.055	0.050
OH	0.047	0.022	0.047	0.043
NH2	0.020	0.013	0.061	0.035
range	0.046	0.023	0.029	0.025
average	0.048	0.024	0.046	0.040
SD	0.013	0.006	0.010	0.009

^aEntries in bold underline the obtained values for unsubstituted adenine and purine tautomers.