Table 1.
Associations between CAD PRS and incident events
| Outcome | No CAD at baseline (N = 393 108) ORa (95% CI) | Prevalent CAD cases (N = 10 287) ORa (95% CI) | Heterogeneity P-value |
|---|---|---|---|
| CAD death/MI | 1.33 (1.29, 1.38) | 1.11 (1.03, 1.20) | 1.4 × 10−5 |
| CV death | 1.20 (1.14, 1.26) | 0.97 (0.87, 1.09) | 0.0012 |
| All-cause death | 1.01 (0.99, 1.03) | 0.91 (0.85, 0.98) | 0.0041 |
| CAD death | 1.31 (1.23, 1.40) | 0.96 (0.85, 1.08) | 9.1 × 10−6 |
| MI | 1.34 (1.29, 1.38) | 1.15 (1.06, 1.25) | 0.0012 |
| Revasc | 0.99 (0.97, 1.01) | 0.91 (0.84, 1.00) | 0.067 |
| Heart failure | 1.00 (0.93, 1.08) | 0.97 (0.86, 1.10) | 0.67 |
| Stroke | 1.05 (1.01, 1.09) | 0.88 (0.78, 1.00) | 0.0094 |
| Ischaemic stroke | 1.09 (1.04, 1.15) | 0.78 (0.67, 0.90) | 1.8 × 10−5 |
| All CVD | 1.06 (1.04, 1.08) | 0.99 (0.93, 1.04) | 0.013 |
aAll OR per 1 SD increase in CAD PRS of 182 SNPs.