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. Author manuscript; available in PMC: 2020 May 28.
Published in final edited form as: ACS Chem Biol. 2019 Nov 12;14(12):2737–2744. doi: 10.1021/acschembio.9b00663

Figure 1.

Figure 1.

Identification of regorafenib-glucuronide processing GUS enzymes. (A) Structure of N-linked regorafenib-glucuronide with the glucuronide moiety highlighted in green. (B) Sequence similarity network (SSN) highlighting reactive GUS enzymes. SSN contains 279 GUS enzymes identified through the Human Microbiome Project (circles). Triangles are GUS enzymes tested. Yellow triangles are GUS enzymes that can reactivate regorafenib-glucuronide. SSN is color-coded by loop categorization defined previously. (C) kcatapparent rates of tested GUS enzymes.