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. Author manuscript; available in PMC: 2020 May 28.
Published in final edited form as: ACS Chem Biol. 2019 Nov 12;14(12):2737–2744. doi: 10.1021/acschembio.9b00663

Table 1.

Rates of Regorafenib-Glucuronide Processing by FpL2-6, H11G11, Rg3, and Rh2 GUS Enzymes

GUS kcat/Km (s−1 M−1)
R. gnavus3 9900 ± 500
R. hominis2 4870 ± 200
H11G11 3540 ± 300
FpL2-6 121 ± 10