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. 2020 Apr 29;44(1):139–155. doi: 10.3892/or.2020.7601

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — miR-193b suppresses proliferation and colony formation of osteosarcoma cells, and inhibits tumor growth in a xenograft model. (A) miR-193b expression was lower in F5M2 cells compared with F4 cells. (B) Overexpression of miR-193b reduced colony formation of F5M2 cells, whereas downregulation of miR-193b enhanced colony formation of F4 cells. (C) Transient and stable transfection efficiencies of miR-193b mimic or inhibitor were quantified. (D) Transient or stable transfection of miR-193b mimic in F5M2 cells inhibited proliferation, whereas transfection of miR-193b inhibitor in F4 cells enhanced cell proliferation. (E) Representative images illustrating tumor formation in a nude mouse xenograft model on day 35. (F) Tumor volume and (G) tumor weight were lower in mice injected with miR-193b-upregulated F5M2 cells. Data are presented as the mean ± SD of at least three independent experiments. *P<0.05. LV, lentivirus; miR-193b, microRNA-193b; NC, negative control.

Figure 1. — miR-193b suppresses proliferation and colony formation of osteosarcoma cells, and inhibits tumor growth in a xenograft model. (A) miR-193b expression was lower in F5M2 cells compared with F4 cells. (B) Overexpression of miR-193b reduced colony formation of F5M2 cells, whereas downregulation of miR-193b enhanced colony formation of F4 cells. (C) Transient and stable transfection efficiencies of miR-193b mimic or inhibitor were quantified. (D) Transient or stable transfection of miR-193b mimic in F5M2 cells inhibited proliferation, whereas transfection of miR-193b inhibitor in F4 cells enhanced cell proliferation. (E) Representative images illustrating tumor formation in a nude mouse xenograft model on day 35. (F) Tumor volume and (G) tumor weight were lower in mice injected with miR-193b-upregulated F5M2 cells. Data are presented as the mean ± SD of at least three independent experiments. *P<0.05. LV, lentivirus; miR-193b, microRNA-193b; NC, negative control.