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. 2020 May 15;10(13):6035–6047. doi: 10.7150/thno.41096

Figure 3.

Figure 3

Cell viability after transplantation into a mouse critical size cranial defect model. (A). BLI of mice that implanted with ASC-laden μRB scaffold or injected with ASC-laden μRB scaffold (with and without BMP-2 incorporation) across different time points. (B). Quantitative data from (A). a, p<0.001, Day 10 vs Day 1 in mice treated with implanted μRBs; b, p<0.05, Day 10 vs Day 1 in mice treated with injected μRBs; c, p<0.001, Day 7 vs Day 1 in mice treated with injected μRBs+BMP-2; d, p<0.001, mice treated with injected μRBs+BMP-2 vs mice treated with injected μRBs; e, p<0.001, mice treated with injected μRBs+BMP-2 vs mice treated with implanted μRBs; All data are presented as mean±S.D. N=5 per group. (C). Immunostaining of luciferase in cranial defect mice implanted with ASC-laden μRB scaffold or injected with ASC-laden μRB scaffold (with and without BMP-2) at day 3, 7 and 14. Bar=50 μm.