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. 2020 Apr 27;10(13):5879–5894. doi: 10.7150/thno.43894

Figure 2.

Figure 2

IL-22 regulates metabolic reprogramming-related transcriptional responses. (A) Heat map of the remarkably altered genes in hepatocytes with injury factors-challenged groups versus IL-22 plus injury factors-challenged groups. (B) Kyoto Encyclopedia of Genes and Genomes analysis (KEGG) of IL-22 targets in hepatocytes with IL-22-protected and -nonprotected groups. (C and D) KEGG of glycolysis and AMPK signaling pathway in IL-22-protected and -nonprotected hepatocytes. (E) Heat map of top altered genes from hepatocytes with IL-22 treatment. (F) Relative mRNA expression level of HK-2, HIF-1α, c-Myc and mtDNA in the absence or presence of IL-22 treatment (n = 3); Student's t test (unpaired); *P < 0.05, **P < 0.01. All data are means ± SD of at least three independent experiments.