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. 2020 Apr 27;10(13):5802–5814. doi: 10.7150/thno.44772

Figure 1.

Figure 1

In vitro and in vivo evidence of the higher cytotoxic potential of α-RIT compared to β-RIT A. Viability of BxPC3 PDAC cells after a 48 hours incubation with various activity concentration of [177Lu]Lu-DOTA-5B1 and [225Ac]Ac-DOTA-5B1 (n=4 per concentration). B. Clonogenic survival of BxPC3 cells exposed to [177Lu]Lu-DOTA-5B1 (n=6 per concentration). C. Clonogenic survival of BxPC3 cells exposed to [225Ac]Ac-DOTA-5B1 (n=6 per concentration). D. Schematic representation of the PRIT dosing schedule. E. Percent survival as function of time after PRIT injection. Mice were sacrificed when tumor >2000 mm3. Survival data reflect the progression of primary subcutaneous tumors (n=8 per cohort). Values are represented as means, and error bars represent standard deviations.