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UBTD1 mediates matrix stiffness-induced effects on HCC cells. (A) CXCR4 knockdown reversed high stiffness-induced UBTD1 down-regulation. (B) MTT assay was used to confirm that UBTD1 overexpression inhibited the proliferation of Hep3B and Huh7 cells. UBTD1 overexpression inhibited PCNA and CyclinD1 expression (C), EMT (D), and stemness (E) associated markers in Hep3B and Huh7 cells. *P < 0.05.
