Figure 5.

PRESA eradicated resistant E. coli in a mouse intestine infection model. (A) MG1655 pUCtarget_k cells in the mouse intestine were treated with vB_Cas9 or the WT temperate phage. Data represent the concentration of pUCtarget_k per gram of stool sample collected from each mouse (n = 6, mean ± SD). (B) The mouse intestine was treated with PRESA, lytic phage vB_253, kanamycin, vB_Cas9 or the PBS control. Data represent the logarithm value of bacterial cell counts per gram stool sample (n = 3, mean ± SD).