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. 2020 May 16;10(14):6483–6499. doi: 10.7150/thno.44025

Figure 5.

Figure 5

STIM1 deficiency rewires aerobic glycolysis towards FAO. (A-C) ECAR (A), OCR (B) and FAO (C) caused by STIM1 deficiency in SMMC7721 and HepG2 cells were measured by Seahorse XF24 analyzer. Oligo: Oligomycin, 2-DG: 2-Deoxy-D-glucose, Fccp: Carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone, AA/Rot: Antimycin A/Rotenone. (D, E) The glucose uptake (D) and intracellular lipid content (E) in WT- and STIM1 KO-SMMC7721 or HepG2 cells were determined by fluorescence microscope and FACS. Data are expressed as mean ± SEM (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001.