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. 2020 May 15;10(14):6201–6215. doi: 10.7150/thno.46137

Figure 9.

Figure 9

Procaterol inhibits gastric tumor growth via MAPK signaling pathway verified in PDXs tumors. A. H&E staining and IHC staining of Ki67, p-MEK, p-ERK in PDX tumor tissues. Representative images are shown. 100 × magnification. B. Proposed schematic diagram of CDK12 in whole study. CDK12 binds with and phosphorylates PAK2 at Threonine134/169 to activate MAPK signaling pathway such as p-MEK and p-ERK. This leads to the acceleration of cell proliferation and tumor growth in gastric tumor with high level of CDK12 (left). CDK12 inhibition by procaterol suppresses PAK2 phosphorylation and MAPK signaling (right). Data represent means ±SD. P<0.05: *, p<0.01: **, p<0.001: ***. Significance determined by two-tailed Student's t test.