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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Hum Genet. 2019 Oct 29;65(2):99–113. doi: 10.1038/s10038-019-0692-3

Fig. 1.

Fig. 1

COX-2 chromosome location and linkage disequilibrium of SNPs. a Location of prostaglandin-endoperoxide synthase 2 (PTGS2; COX-2) on chromosome 1q31. COX-2 is 8,616 bp and is composed of 10 exons. Chromosome position (build GRCh38.p12) for the selected SNPs under investigation; rs20420 (−512 C > T) is located at 186680936, rs20419 (−608 T > C) located at 186681031, rs20417 (−765 G > C) located at 186681189 and rs689466 (−1195 A > G) located at 186681619. The alignment and gene structure of COX-2 are based the Golden Helix Genome Browse 1.0.1. b COX-2 genotypes minor allele frequencies (MAF) from the International HapMap project for the Kenyan [Luhya (LWK) and Maasai (MKK)] populations and Yoruba (YRI; Nigeria). MAFs from the 1000 Genome project shows African (AFR) ancestry and global allele frequencies. c Transcription factor binding analyses of the COX-2 variants. NF-E Eucaryotic nuclear factor, GR Glucocorticoid receptor, LEF Lymphocyte enhancing factor, LVa Lava lamp, TCF T-cell factor, SP1 stimulatory protein 1, E2F E2F transcription factor family, CTCF CCCTC binding factor, c-Myb MYB proto-oncogene, and MyoD myogenic differentiation. d Linkage disequilibrium between the selected COX-2 SNPs: −512 C > T and −608 T > C (D′: −0.6646, r2: 0.00886); −512 C > T and −765 G > C (D′: 0.6709, r2: 0.07556); −512 C > T and −1195 A > G (D′: 0.0148, r2: 0.00015); −608 T > C and −765 G > C (D′: −0.4787, r2: 0.02736); −608 T > C and −1195 A > G (D′: −0.3384, r2: 0.00154), and −765 G > C and −1195 A > G (D′: −0.3934, r2: 0.00517).