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. Author manuscript; available in PMC: 2021 Mar 17.
Published in final edited form as: Anal Chem. 2020 Feb 26;92(6):4217–4225. doi: 10.1021/acs.analchem.9b04418

Figure 4.

Figure 4.

Quantitative proteomic analysis of PDX models (basal and luminal subtypes) using 2D-DIA. (A) The total number of identified protein groups that were human-only (green), from either human or mouse (yellow) or mouse-only (orange). The number of proteins with a quantification CV < 20% (dashed bars). (B) Volcano plot showing the Fold Change and the p-values (t test) between the basal and luminal subtypes. The known breast cancer markers were highlighted in red. (C) Hierarchical clustering analysis for protein expression between the basal and luminal subtypes. (D) Gene ontology analysis of up- and down-regulated proteins in the basal vs luminal subtype.