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. 2020 May 21;10:820. doi: 10.3389/fonc.2020.00820

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Copyright © 2020 Carafa, Russo, Della Torre, Cuomo, Dell'Aversana, Sarno, Sgueglia, Di Donato, Rotili, Mai, Nebbioso, Cobellis, Chambery and Altucci.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Orthogonal ATP assays. (B) ATPase assay. U937 were treated with MC2494 at 25 μM concentration for indicated times. (C) Intracellular calcium assay. U937 were treated with MC2494 at 25 μM concentration for 24 h. (D) Proton leak evaluation. (E) Seahorse ATP production assay, OCR and ECAR evaluation. U937 were treated with MC2494 at 25 μM concentration for indicated times. Values are mean ± standard deviation (SD) of biological triplicates. ^**p ≤ 0.01, ^*p ≤ 0.05 vs. control cells. (F) Schematic representation of MC2494 effects on mitochondrial biological activity.