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Manifestations of cardiac fibrosis. Schematic of the three main types of cardiac fibrosis. Replacement fibrosis develops to fill necrotic lesions within the myocardium as a result of ischemia, infection, or trauma. Interstitial fibrosis develops in the interstitial space of the myocardium as a result of non-ischemic cardiomyopathies. Perivascular fibrosis develops in the peri-adventitial space as a result of non-ischemic cardiomyopathies.
