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. 2020 Apr 1;9(1):1744947. doi: 10.1080/2162402X.2020.1744947

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — HLA genotyping and neoantigen profiling in 835 TCGA BRCA tumors. (a) The number of unique HLA genotypes in the 835 TCGA BRCA patients. (b) Distribution of the number of class-I and class-II HLA genotypes per patient. (c) Total number of neoantigens in the BRCA cohort, stratified by: (i) type of somatic mutations: SNM, INDEL, and gene fusion from which neoantigens arose; and (ii) the class of HLA molecules neoantigens bind to. (d) The numbers of class-I (top panel) and class-II (bottom panel) neoantigens per patient, stratified by somatic mutation types of SNM, INDEL and Fusion. The x-axis is in Log2 scale.