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. 2020 Apr 1;9(1):1744947. doi: 10.1080/2162402X.2020.1744947

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© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Neoantigen load and BRCA1/2 mutation status, BRCA subtypes and immune subtypes. (a) BRCA1 and BRCA2 mutation status and overall mutation burden. Left panel: patients with known deleterious BRCA1 or BRCA2 germline mutations (labeled as Mutated, dark purple) had suggestive higher overall mutation burden than patients without (labeled as WT, light purple) (p = .067). Right panel: patients with known deleterious BRCA1 or BRCA2 germline and somatic mutations (labeled as Mutated, dark blue) had significantly higher overall mutation burden than patients without (labeled as WT, light blue) (p = 2.67E-06). (b) BRCA1 and BRCA2 mutation status and neoantigen load. Left panel: patients with known deleterious BRCA1 or BRCA2 germline mutations (labeled as Mutated, dark yellow) did not show significant difference in neoantigen load from patients without (labeled as WT, light yellow). Right panel: patients with known deleterious BRCA1 or BRCA2 germline and somatic mutations (labeled as Mutated, dark green) had significantly higher neoantigen load than patients without (labeled as WT, light green) (p = .009). (c) Breast cancer subtype and neoantigen load. Significant differences in neoantigen load were found between Basal and LumA (p = 4.04E-05), Her2 and LumA (p = .005), LumA and LumB (p = 4.31E-06), and LumA and Normal (p = .0003). (d) Immune subtype and neoantigen load. Significant differences in neoantigen load were found between C1 and C3 (p = .01), C2 and C3 (p = .001), and C1 and C6 (p = .03).