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. 2020 Apr 1;9(1):1744947. doi: 10.1080/2162402X.2020.1744947

Table 1.

Neoantigens in BRCA driver genes.

Gene Number of patients with NS mutations Number of NS mutations Total number of neoantigens Number of class-I neoantigens in >1% patients Number of class-II neoantigens in >1% patients Number of class-I neoantigens in >5% patients Number of class-II neoantigens in >5% patients MutSig (q-value)
TP53 227 288 2392 46 206 0 0 2.12E-12
PIK3CA 237 250 2825 6 31 0 7 2.12E-12
CDH1 97 167 3045 146 618 0 0 1.76E-11
GATA3 86 157 908 8 50 0 0 2.12E-12
MAP3K1 72 123 4644 167 579 0 0 1.40E-10
RUNX1 36 60 1377 0 0 0 0 1.88E-12
ERBB2 37 55 10,875 0 0 0 0 6.67E-07
NCOR1 36 51 5902 0 0 0 0 1.10E-04
TBX3 24 44 1210 0 61 0 0 2.21E-11
PIK3R1 25 42 346 0 0 0 0 1.66E-03
RB1 26 41 3095 0 0 0 0 1.42E-03
FOXA1 25 31 413 0 0 0 0 2.12E-12
GPRIN2 21 31 431 1 109 0 0 8.70E-02
MAP2K4 22 31 728 0 0 0 0 1.32E-11
SF3B1 21 28 405 0 0 0 0 2.12E-12
HLA-DRB5 25 28 162 0 0 0 0 8.33E-02
ZFP36L1 14 26 1727 0 0 0 0 1.00E-02
CBFB 16 20 303 0 0 0 0 2.12E-12
TBL1XR1 11 19 3254 0 0 0 0 2.10E-02
CTCF 14 19 866 0 0 0 0 2.98E-02
GPS2 10 18 425 0 0 0 0 1.28E-04
ASXL2 10 15 3454 0 0 0 0 4.98E-02
MYB 10 15 996 0 0 0 0 2.40E-02
CDKN1B 8 15 374 0 0 0 0 2.10E-05
CASP8 14 15 302 0 0 0 0 3.18E-02
FAM86B1 14 14 91 0 0 0 0 1.09E-02
FAM20 C 6 9 218 0 0 0 0 5.83E-02
FBXW7 7 9 222 0 0 0 0 1.22E-02
HIST1H2BC 7 7 73 0 0 0 0 5.43E-02
KRAS 6 7 38 0 0 0 0 2.33E-03
ZFP36L2 6 7 103 0 0 0 0 8.69E-03
WSCD2 6 6 51 0 0 0 0 3.23E-02
PTGER2 3 3 43 0 0 0 0 2.52E-02
AQP12A 1 2 107 0 0 0 0 9.37E-04
ZP4 2 2 4 0 0 0 0 3.64E-02
RAB42 1 2 3 0 0 0 0 9.32E-02
PTEN 1 2 1203 0 0 0 0 2.72E-12