Table 2.
Information of hub target genes of SHL oral liquid.
| Hub Gene | Protein names | Degree | UniPort Entry |
|---|---|---|---|
| CYP1A1 | Cytochrome P450 | 13 | Q0VHD5 |
| CCNB1 | G2/mitotic-specific cyclin-B1 | 13 | H0Y9U8 |
| NCOA2 | Nuclear receptor coactivator 2 | 13 | A0A1D5RMT0 |
| ERBB2 | Receptor tyrosine-protein kinase erbB-2 | 13 | J3KTI5 |
| PSMD3 | 26S proteasome non-ATPase regulatory subunit 3 | 13 | F5H8K4 |
| GSK3B | Glycogen synthase kinase-3 beta | 13 | A0A3B3ITW1 |
| F2 | F2 Protein | 13 | E9PIT3 |
| MDM2 | MDM2 protein | 14 | A0A0A8KA17 |
| PTK2 | Focal adhesion kinase 1 | 14 | E7ESA6 |
| MYC | V-myc myelocytomatosis viral oncogene homolog | 14 | B3CJ87 |
| CASP3 | Caspase-3 | 15 | A8MVM1 |
| AR | Androgen receptor splice variant 5 | 16 | C0JKD6 |
| NCOA1 | Nuclear receptor coactivator 1 | 16 | B5MCN7 |
| CCND1 | G1/S-specific cyclin-D1 | 17 | F5H437 |
| NR3C1 | Glucocorticoid nuclear receptor variant 1 | 17 | F1D8N4 |
| MAPK8 | Mitogen-activated protein kinase 8 | 17 | A0A3B3IRW7 |
| RELA | Transcription factor p65 | 19 | A0A087WVP0 |
| FOS | Proto-oncogene c-Fos | 19 | H0YJM3 |
| VEGFA | Vascular endothelial growth factor A | 20 | H0YBI8 |
| CDK1 | Cyclin-dependent kinase 1 | 20 | A0A087WZZ9 |
| CTNNB1 | Catenin beta-1 | 22 | A0A2R8Y804 |
| EGFR | Epidermal growth factor receptor | 22 | A7VN06 |
| ESR1 | Estrogen receptor protein | 23 | K7R989 |
| APP | Amyloid beta A4 protein | 25 | L7XE61 |
| AKT1 | RAC-alpha serine/threonine-protein kinase | 26 | A0A087WY56 |
| PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 28 | E5RK66 |
| SRC | Tyrosine kinase pp60c-src | 34 | Q71UK5 |
| TP53 | Cellular tumor antigen p53 | 40 | J3KP33 |