Table 3.

Multivariate Cox Regression for the Ovary Cancer Patients with Brain Metastases

Variables	Patients, No.		All-Cause Mortality (model 1)		All-Cause Mortality (model 2)
	Patients (N=29512)	With Brain Metastases (N=89)	HR (95%CI)	P value	HR (95%CI)	P value
Marital status
Married	14188	35	Reference		Reference
Single	6565	22	0.679(0.351-1.313)	0.249	0.643(0.327-1.264)	0.200
Divorced	2990	8	2.688(1.102-6.560)	0.030	2.672(1.027-6.953)	0.044
Widowed	4424	17	0.710(0.355-1.419)	0.332	0.659 (0.324-1.341)	0.250
Unknown	1345	7	0.515(0.185-1.429)	0.202	0.485(0.170-1.384)	0.176
Histology
Epithelial neoplasms	26303	67	Reference		Reference
Gonadal neoplasms	1297	2	0.215(0.028-1.670)	0.142	0.215(0.028-1.675)	0.142
Others	1071	3	1.183(0.144-9.737)	0.876	0.998(0.105-9.486)	0.999
Unknown	841	17	0.921(0.480-1.766)	0.804	0.906(0.465-1.767)	0.906
Treatment
Others	3371	37	NA	NA	Reference	NA
CSR	213	13	NA	NA	0.096(0.030-0.308)	<0.0001
RS	24	3	NA	NA	0.283(0.060-1.342)	0.112
SC	17127	5	NA	NA	0.081 (0.021-0.312)	<0.0001
RC	77	15	NA	NA	0.260(0.115-0.587)	0.001
R	38	6	NA	NA	1.015(0.357-2.886)	0.978
S	5647	2	NA	NA	0.207 (0.040-1.086)	0.063
C	3015	8	NA	NA	0.428(0.167-1.101)	0.078
Surgery
U/BSO	12146	14	Reference		NA	NA
Cytoreductive	10360	9	1.042(0.317-3.421)	0.946	NA	NA
Others	505	0	NA	NA	NA	NA
No	6501	66	3.712(1.519-9.075)	0.004	NA	NA
Radiotherapy					NA	NA
No	29160	52	Reference		NA	NA
Yes	352	37	0.893(0.481 -1.657)	0.720	NA	NA
Chemotherapy
No	9080	48	Reference		NA	NA
Yes	20432	41	0.341(0.169-0.687)	0.003	NA	NA
Insurance situation
No	1096	7	Reference		Reference
Yes	27927	77	0.776(0.315-1.912)	0.582	0.754(0.281-2.020)	0.574
Unknown	489	5	0.965(0.255-3.655)	0.958	0.984 (0.242-4.006)	0.984

Abbreviations:

CI: confidence interval.