Table 5.
Univariate and multivariate Cox Regression for the Brain Metastases of Ovary Cancer after PSM.
| Variables | Univariate | Multivariate in model 1 | Multivariate in model 2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value | |||||
| Age (years) | ||||||||||
| 18-58 | Reference | Reference | Reference | |||||||
| ≥59 | 1.575(1.086-2.283) | 0.017 | 0.719 (0.418-1.237) | 0.233 | 0.752(0.435-1.298) | 0.306 | ||||
| Marital status | ||||||||||
| Married | Reference | Reference | Reference | |||||||
| Single | 0.762(0.470-1.233) | 0.268 | 0.599(0.344-1.043) | 0.070 | 0.548(0.317-0.948) | 0.031 | ||||
| Divorced | 2.163(1.201-3.894) | 0.010 | 1.977(0.977-4.003) | 0.058 | 1.882(0.890-3.981) | 0.098 | ||||
| Widowed | 1.665(1.081-2.563) | 0.021 | 1.073(0.629-1.829) | 0.797 | 1.002(0.583-1.723) | 0.994 | ||||
| Unknown | 0.976(0.476-1.999) | 0.946 | 0.567(0.238-1.347) | 0.199 | 0.532(0.220-1.288) | 0.162 | ||||
| Race | ||||||||||
| White | Reference | NA | NA | NA | NA | |||||
| Black | 0.829(0.513-1.340) | 0.443 | NA | NA | NA | NA | ||||
| Others | 1.470(0.766-2.820) | 0.247 | NA | NA | NA | NA | ||||
| Unknown | 0.466(0.065-3.348) | 0.448 | NA | NA | NA | NA | ||||
| Origin recode | ||||||||||
| Hispanic | Reference | Reference | Reference | NA | ||||||
| Non-hispanic | 1.535(0.805-2.928) | 0.193 | 0.798(0.369-1.727) | 0.298 | 0.923(0.428-1.990) | 0.837 | ||||
| Laterality | ||||||||||
| Unilateral | Reference | Reference | Reference | NA | ||||||
| Bilateral | 0.777(0.472-1.278) | 0.320 | 0.694(0.379-1.270) | 0.236 | 0.743(0.401-1.378) | 0.346 | ||||
| Unknown | 1.153(0.788-1.687) | 0.463 | 1.119(0.679-1.846) | 0.659 | 1.112(0.673-1.837) | 0.678 | ||||
| Tumor staging | ||||||||||
| I | Reference | NA | NA | NA | NA | |||||
| II | 0.904(0.000-2.159E67) | 0.999 | NA | NA | NA | NA | ||||
| III | 1856.939(0.000-2.6481E61) | 0.912 | NA | NA | NA | NA | ||||
| IV | 3401.073(0.000-4.837E+61) | 0.905 | NA | NA | NA | NA | ||||
| Unknown | 1933.002(0.000-2.751E+61) | 0.912 | NA | NA | NA | NA | ||||
| T staging | ||||||||||
| T1 | Reference | Reference | NA | Reference | NA | |||||
| T2 | 0.759(0.355-1.621) | 0.477 | 0.794(0.335-1.882) | 0.600 | 0.872(0.365-2.082) | 0.757 | ||||
| T3 | 0.890(0.476-1.662) | 0.714 | 0.921(0.430-1.973) | 0.832 | 1.007(0.481-2.108) | 0.985 | ||||
| Unknown | 1.047(0.576-1.902) | 0.880 | 0.687(0.315-1.499) | 0.346 | 0.697(0.324-1.503) | 0.358 | ||||
| N staging | ||||||||||
| N0 | Reference | Reference | NA | Reference | NA | |||||
| N1 | 1.203(0.779-1.856) | 0.405 | 1.165(0.690-1.965) | 0.568 | 1.183(0.697-2.011) | 0.533 | ||||
| Unknown | 1.473(0.975-2.225) | 0.066 | 1.013(0.609-1.685) | 0.960 | 1.006(0.601-1.684) | 0.981 | ||||
| Histology | ||||||||||
| Epithelial neoplasms | Reference | Reference | Reference | NA | ||||||
| Gonadal neoplasms | 0.324(0.045-2.323) | 0.262 | 0.192(0.024-1.508) | 0.117 | 0.176(0.022-1.392) | 0.100 | ||||
| Others | 0.696(0.323-1.499) | 0.355 | 0.793(0.302-2.079) | 0.637 | 0.976(0.376-2.535) | 0.960 | ||||
| Unknown | 1.293(0.824-2.030) | 0.264 | 0.592(0.336-1.043) | 0.070 | 0.606(0.342-1.072) | 0.085 | ||||
| Treatment | ||||||||||
| Others | Reference | NA | NA | Reference | ||||||
| CSR | 0.209(0.112-0.390) | <0.0001 | NA | NA | 0.104(0.045-0.236) | <0.0001 | ||||
| RS | 0.555(0.136-2.275) | 0.414 | NA | NA | 0.350 (0.069-1.783) | 0.206 | ||||
| SC | 0.224(0.081-0.620) | 0.004 | NA | NA | 0.061(0.018-0.212) | <0.0001 | ||||
| RC | 0.357(0.215-0.595) | <0.0001 | NA | NA | 0.231(0.124-0.429) | <0.0001 | ||||
| R | 0.863(0.443-1.683) | 0.666 | NA | NA | 0.710(0.307-1.641) | 0.423 | ||||
| S | 0.340(0.136-0.847) | 0.021 | NA | NA | 0.231(0.070-0.763) | 0.016 | ||||
| C | 0.502(0.285-0.884) | 0.017 | NA | NA | 0.310(0.158-0.608) | 0.001 | ||||
| Surgery | ||||||||||
| U/BSO | Reference | Reference | NA | NA | ||||||
| Cytoreductive | 1.117(0.483-2.582) | 0.797 | 1.120 (0.427-2.938) | 0.818 | NA | NA | ||||
| Others | 0.000(0.000- 4.8509E168) | 0.959 | 0.000(0.000-7.797E+183) | 0.961 | NA | NA | ||||
| No | 2.743(1.564-4.810) | <0.0001 | 3.141(1.433-6.886) | 0.004 | NA | NA | ||||
| Radiotherapy | ||||||||||
| No | Reference | Reference | NA | NA | ||||||
| Yes | 0.499(0.347-0.717) | <0.0001 | 0.817(0.462-1.442) | 0.485 | NA | NA | ||||
| Chemotherapy | ||||||||||
| No | Reference | Reference | NA | NA | ||||||
| Yes | 0.3720.260-0.531() | <0.0001 | 0.298(0.180-0.495) | <0.0001 | NA | NA | ||||
| Radiation Sequence with surgery | ||||||||||
| Others | Reference | Reference | NA | NA | ||||||
| RBS | 0.365(0.090-1.481) | 0.158 | 1.283(0.247-6.660) | 0.767 | NA | NA | ||||
| RAS | NA | NA | NA | NA | NA | NA | ||||
| RBAS | 0.417(0.250-0.697) | 0.001 | 1.151(0.536-2.473) | 0.718 | NA | NA | ||||
| Brain Met | ||||||||||
| No | Reference | Reference | Reference | |||||||
| Yes | 1.327(0.943-1.866) | 0.104 | 1.600(1.042-2.458) | 0.032 | 1.653(1.076-2.541) | 0.022 | ||||
| Bone Met | ||||||||||
| No | Reference | Reference | Reference | |||||||
| Yes | 1.186(0.780-1.805) | 0.425 | 0.951 (0.554 -1.630) | 0.854 | 1.040(0.596-1.814) | 0.891 | ||||
| Unknown | 1.877(0.999-3.528) | 0.050 | 0.977(0.307-3.112) | 0.969 | 0.974(0.297-3.193) | 0.965 | ||||
| Liver Met | ||||||||||
| No | Reference | Reference | Reference | |||||||
| Yes | 1.756(1.187-2.598) | 0.005 | 1.899(1.119-3.223) | 0.018 | 1.941(1.140-3.303) | 0.015 | ||||
| Unknown | 1.995(0.999-3.987) | 0.050 | 1.506(0.535-4.236) | 0.438 | 1.584(0.556-4.508) | 0.389 | ||||
| Lung Met | ||||||||||
| No | Reference | Reference | Reference | |||||||
| Yes | 1.834(1.274-2.641) | 0.001 | 1.374(0.826-2.284) | 0.221 | 1.305(0.785-2.169) | 0.305 | ||||
| Unknown | 1.949(0.934-4.068) | 0.075 | 1.500(0.455-4.941) | 0.505 | 1.436(0.438-4.712) | 0.550 | ||||
| CA125 | ||||||||||
| Normal | Reference | Reference | NA | Reference | NA | |||||
| Elevated | 2.338(0.850-6.428) | 0.100 | 1.543(0.502-4.747) | 0.449 | 1.502(0.488-4.621) | 0.478 | ||||
| Unknown | 2.063(0.747-5.702) | 0.163 | 1.398(0.457-4.275) | 1.398 | 1.387(0.452-4.259) | 0.567 | ||||
| Insurance situation | ||||||||||
| No | Reference | Reference | Reference | |||||||
| Yes | 0.491(0.274-0.878) | 0.017 | 0.701 (0.323-1.522) | 0.369 | 0.704(0.324-1.531) | 0.376 | ||||
| Unknown | 0.644(0.210-1.980) | 0.443 | 0.897(0.234-3.446) | 0.875 | 0.938(0.244-3.607) | 0.926 | ||||
| Residence type | ||||||||||
| Rural | Reference | Reference | NA | Reference | NA | |||||
| Urban | 0.599(0.177-2.023) | 0.409 | 0.956(0.202-4.525) | 0.955 | 0.892(0.182-4.373) | 0.888 | ||||
| Metropolitan | 0.428(0.135-1.359) | 0.150 | 0.587(0.129-2.677) | 0.491 | 0.535(0.112-2.547) | 0.432 | ||||
| Unknown | NA | NA | NA | NA | NA | NA | ||||