Table 3.
Cox's proportional hazards regression model analysis of factors affecting OS.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Gender (Male/Female) | 0.754 | 0.442-1.289 | 0.302 | - | - | - |
| TAI (Yes/No) | 0.884 | 0.540-1.448 | 0.625 | - | - | - |
| Strengthen embolization (Yes/No) | 1.442 | 0.834-2.495 | 0.190 | - | - | - |
| Previous treatment (Yes/No) | 0.491 | 0.286-0.841 | 0.010 | - | - | - |
| Subsequent treatment (Yes/No) | 0.408 | 0.236-0.703 | 0.001 | 0.519 | 0.298-0.903 | 0.020 |
| Combined treatment (Yes/No) | 0.445 | 0.272-0.728 | 0.001 | - | - | - |
| Tumor location(Unilateral/Bilateral) | 1.025 | 0.623-1.687 | 0.922 | - | - | - |
| Tumor No. (1/≥2) | 1.247 | 0.749-2.078 | 0.396 | - | - | - |
| Tumor size (≤5 cm/>5 cm) | 2.943 | 1.682-5.147 | 0.000 | - | - | - |
| Vascular invasion (Yes/No) | 2.467 | 1.517-4.011 | 0.000 | - | - | - |
| Extrahepatic metastasis (Yes/No) | 2.011 | 1.232-3.280 | 0.005 | 1.776 | 1.049-3.008 | 0.033 |
| Cholangiectasis (Yes/No) | 3.215 | 1.913-5.403 | 0.000 | 2.718 | 1.597-4.626 | 0.000 |
| CA-125 (≤35 U/ml />35 U/ml) | 1.658 | 1.019-2.700 | 0.042 | - | - | - |
| CA-199 (≤37 U/ml />37 U/ml) | 2.145 | 1.314-3.502 | 0.002 | - | - | - |
| Tumor burden | 0.000 | 0.011 | ||||
| ≤25% | Ref | Ref | ||||
| >25%, ≤50% | 1.763 | 1.035-3.005 | 0.037 | 1.274 | 0.724-2.240 | 0.401 |
| >50% | 4.703 | 2.429-9.107 | 0.000 | 2.953 | 1.482-5.884 | 0.002 |
Data were presented as P value, HR (hazards ratio) and 95% CI (confidence interval). Factors affecting OS (overall survival) were determined by univariate and multivariate Cox's proportional hazards regression model analyses. P-value <0.05 was considered significant. CA-125, carbohydrate antigen 125; CA-199, carbohydrate antigen 199; TAI, transcatheter arterial infusion.