Table 3.
COX proportional hazard models on overall survival of lung AC patients.
| Factors | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| P value | HR (95%CI) | P value | HR (95%CI) | |
| Gender | ||||
| Male vs. Female | 0.968 | 1.013 (0.544-1.887) | 0.275 | 1.644 (0.673-4.015) |
| Age | ||||
| <= 64vs. >64 | 0.037 | 1.998 (1.041-3.834) | 0.309 | 1.453 (0.708-2.984) |
| PKM2 expression in tumor cells | ||||
| Low vs. High | <0.001 | 3.772 (1.794-7.930) | 0.005 | 4.242 (1.550-11.609) |
| PD-L1 expression in tumor cells | ||||
| Low vs. High | 0.047 | 1.909 (1.008-3.615) | 0.052 | 2.148 (0.992-4.651) |
| PKM2 and PD-L1 co-expression in tumor cells | ||||
| Both low vs. both high vs. other | ||||
| 0.024 | 1.519 (1.058-2.181) | 0.716 | 1.113 (0.626-1.976) | |
| PKM2 expression in immune cells | ||||
| Low vs. High | 0.019 | 2.320 (1.148-4.689) | - | - |
| PD-L1 expression in immune cells | ||||
| Low vs. High | 0.030 | 2.218 (1.081-4.554) | - | - |
| PKM2 and PD-L1 co-expression in immune cells | ||||
| Both low vs. both high vs. other | ||||
| 0.017 | 1.536 (1.081-2.182) | - | - | |
| Depth of invasion(T) | ||||
| T1,T2 vs. T3,T4 | 0.021 | 2.685 (1.163-6.198) | 0.578 | 1.539 (0.337-7.020) |
| Lymph node metastasis(N) | ||||
| N0 vs. N1,N2 | 0.233 | 1.456 (0.785-2.703) | 0.381 | 2.241 (0.368-13.638) |
| TNM stage | ||||
| I,II vs. III | 0.053 | 1.836 (0.993-3.395) | 0.297 | 0.331 (0.042-2.639) |
| Smoking history | ||||
| Yes vs. No | 0.537 | 0.820 (0.437-1.539) | 0.607 | 0.782 (0.307-1.991) |
| Histological type | ||||
| Invasive vs. Variant | 0.303 | 1.578 (0.662-3.759) | 0.691 | 1.172 (0.535-2.567) |