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Candidate methylation sites selection using the LASSO Cox regression model. (A) 10-fold cross-validation for tuning parameter selection in the LASSO model via minimum criteria (the 1-SE criteria). (B) LASSO coefficient profiles of the 51 methylation sites. A coefficient profile plot was produced against log (lambda) sequence. Vertical line was drawn at the value selected using 10-fold cross-validation, where optimal lambda resulted in 17 non-zero coefficients.
