Table 3.
Association between single nucleotide polymorphisms (SNPs) and lung cancer progression (n=305)
| Gene/SNP | Genotype | T stage | N stage | M stage | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T1/T2 | T3/T4 | OR (95% CI) | P | N0 | N1/N2/N3 | OR (95% CI) | P | M0 | M1 | OR (95% CI) | P | ||
| HMGB1 | |||||||||||||
| rs1045411 | GG | 59 | 130 | Ref. | 39 | 150 | Ref. | 51 | 138 | Ref. | |||
| AG/AA | 57 | 59 | 0.47 (0.29-0.76) | 0.002 | 16 | 100 | 1.63 (0.86-3.07) | 0.134 | 37 | 79 | 0.79 (0.48-1.31) | 0.358 | |
| rs1412125 | TT | 58 | 100 | Ref. | 35 | 123 | Ref. | 45 | 113 | Ref. | |||
| CT/CC | 58 | 89 | 0.89 (0.56-1.41) | 0.622 | 20 | 127 | 1.81 (0.99-3.30) | 0.054 | 43 | 104 | 0.96 (0.59-1.58) | 0.882 | |
| CC | 6 | 11 | Ref. | 2 | 15 | Ref. | 3 | 14 | Ref. | ||||
| CT/TT | 110 | 178 | 0.88 (0.32-2.45) | 0.811 | 53 | 235 | 0.59 (0.13-2.66) | 0.494 | 85 | 203 | 0.51 (0.14-1.83) | 0.302 | |
| rs2249825 | CC | 79 | 150 | Ref. | 45 | 184 | Ref. | 65 | 164 | Ref. | |||
| GC/GG | 37 | 39 | 0.56 (0.33-0.94) | 0.028 | 10 | 66 | 1.61 (0.77-3.39) | 0.205 | 23 | 53 | 0.91 (0.52-1.61) | 0.754 | |
| REV3L | |||||||||||||
| rs462779 | CC | 28 | 48 | Ref. | 7 | 69 | Ref. | 18 | 58 | Ref. | |||
| TC/TT | 88 | 141 | 0.94 (0.55-1.60) | 0.805 | 48 | 181 | 0.38 (0.17-0.89) | 0.025 | 70 | 159 | 0.71 (0.39-1.28) | 0.252 | |
| TT | 30 | 38 | Ref. | 16 | 52 | Ref. | 20 | 48 | Ref. | ||||
| TC/CC | 86 | 151 | 1.39 (0.80-2.40) | 0.242 | 39 | 198 | 1.56 (0.81-3.01) | 0.183 | 68 | 169 | 1.04 (0.57-1.87) | 0.908 | |
| rs465646 | AA | 77 | 118 | Ref. | 34 | 161 | Ref. | 50 | 145 | Ref. | |||
| GA/GG | 39 | 71 | 1.19 (0.73-1.93) | 0.486 | 21 | 89 | 0.90 (0.49-1.64) | 0.718 | 38 | 72 | 0.65 (0.39-1.09) | 0.100 | |
| NFE2L2 | |||||||||||||
| rs6706649 | CC | 99 | 165 | Ref. | 46 | 218 | Ref. | 76 | 188 | Ref. | |||
| CT/TT | 17 | 24 | 0.85 (0.43-1.65) | 0.627 | 9 | 32 | 0.75 (0.34-1.68) | 0.484 | 12 | 29 | 0.98 (0.47-2.01) | 0.950 | |
| rs6721961 | GG | 64 | 88 | Ref. | 33 | 119 | Ref. | 44 | 108 | Ref. | |||
| TG/TT | 52 | 101 | 1.41 (0.89-2.25) | 0.145 | 22 | 131 | 1.65 (0.91-2.99) | 0.098 | 44 | 109 | 1.01 (0.62-1.66) | 0.971 | |
| TT | 13 | 18 | Ref. | 7 | 24 | Ref. | 8 | 23 | Ref. | ||||
| TG/GG | 103 | 171 | 1.20 (0.56-2.55) | 0.637 | 48 | 226 | 1.37 (0.56-3.37) | 0.489 | 80 | 194 | 0.84 (0.36-1.97) | 0.693 | |
| rs35652124 | TT | 38 | 52 | Ref. | 19 | 71 | Ref. | 24 | 66 | Ref. | |||
| CT/CC | 78 | 137 | 1.28 (0.78-2.12) | 0.330 | 36 | 179 | 1.33 (0.72-2.47) | 0.367 | 64 | 151 | 0.86 (0.49-1.49) | 0.586 | |
| CC | 26 | 41 | Ref. | 12 | 55 | Ref. | 24 | 43 | Ref. | ||||
| CT/TT | 90 | 148 | 1.04 (0.60-1.82) | 0.883 | 43 | 195 | 0.99 (0.49-2.01) | 0.976 | 64 | 174 | 1.52 (0.85-2.70) | 0.156 | |
OR, odds ratio; CI, confidence interval; P, P-value for binary logistic regression analysis; Ref., reference. P < 0.05 are indicated in bold text.