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. 2020 May 18;11(15):4431–4441. doi: 10.7150/jca.42308

Figure 4.

Figure 4

miR-206 suppresses function of LncHOTAIR in CRC cells. A. Bioinformatics analysis of HOTAIR and miR-206. B. The mRNA expression levels of miR-206 in SW620 cells were detected by qRT-PCR in LncHOTAIR-silenced group or control group. C. miR-206 showed low expression in CRC tissues compared to normal tissues by qRT-PCR. D. miR-206 showed low expression in CRC cells compared to normal cells by qRT-PCR. E. The mRNA expression levels of LncHOTAIR in SW620 cells were detected by qRT-PCR in miR-206 mimic group, inhibitor group or control group. F. Cell lysates in SW620 and HCT116 cells transfected with wild-type or mutant HOTAIR plasmid and cotransfected with miR-206 mimic or miR-206 inhibitor were assayed for luciferase activity. G. Cell proliferation in SW620 transfected with HOTAIR-silenced and cotransfected with miR-206 mimic, miR-206 inhibitor were tested by CCK-8 assay. H. Cell invasion ability in SW620 transfected with HOTAIR-silenced and cotransfected with miR-206 mimic or miR-206 inhibitor was tested by transwell assays. * P<0.05, ** P<0.01, compared with NC group.