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. 2020 May 18;11(15):4431–4441. doi: 10.7150/jca.42308

Figure 7.

Figure 7

miR-206 attenuated pro-tumorous effects of HOTAIR in colorectal cancer. A. miR-206 overexpression decreased the mRNA expression of CCL2 in HOTAIR-knockdown colorectal cancer cells. B. miR-206 overexpression reduced the protein expression of CCL2 in HOTAIR-knockdown colorectal cancer cells. C. Quantify the relative expression intensity of CCL2 protein. D. CCK-8 assays suggested that miR-206 could effectively accelerate the inhibitory effects of HOTAIR knockdown on proliferation of CRC cells. E. miR-206 accelerated the inhibitory ability of the colony formation in HOTAIR-knockdown CRC cells. F. miR-206 enhanced the suppressive effects of HOTAIR-knockdown on invasion of CRCcells. * P<0.05, ** P<0.01, compared with NC or NC-mimic group.