| Efficacy and safety results obtained from clinical studies on the therapeutic role of HCQ in COVID-19 are not satisfactory. |
| The majority of the published studies have major methodological limitations. |
| Safety aspects associated with the use of HCQ along with azithromycin in COVID-19 warrants caution. |
| Large and robust randomized controlled trials will conclusively determine the role of HCQ in COVID-19. |
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