Table 3.

Characteristics of Attacks Requiring Treatment at a Health Care Facility and/or Hemin Administration Experienced During EXPLORE

Variable	AIP (n = 104)	HCP and VP (n = 8)	Total (n = 112)
Number of attacks	2 (0‐37)	1 (0‐4)	2 (0‐37)
Attack duration per subject (days)	6.7 (3.4)	15.1 (18.1)	7.3 (6.0)
AAR	2.0 (0.0‐37.0)	1.3 (0.0‐4.2)	2.0 (0.0‐37.0)
AAR by region
Europe	1.0 (0‐37.0)	1.2 (1.0‐1.5)	1.0 (0‐37)
US	3.3 (0.0‐15.9)	1.5 (0.0‐4.2)	2.1 (0.0‐15.9)
AAR by hemin prophylaxis*
Yes	2.5 (0.0‐20.0)	3.1 (1.9‐4.2)	2.5 (0.0‐20.0)
No	2.0 (0.0‐37.0)	1.0 (0.0‐2.0)	1.5 (0.0‐37.0)
AAR by daily symptoms†
Yes	2.0 (0.0‐22.3)	1.0 (0.0‐4.2)	2.0 (0.0‐22.3)
No	2.8 (0.0‐37.0)	1.9 (1.0‐2.0)	2.0 (0.0‐37.0)

Data are presented as median (range) or mean (SD). AAR is annualized attack rate, calculated (number of attacks ÷ time on study).

^*At study entry or on study.

^†At study entry.