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. 2020 Apr 15;46(1):224–238. doi: 10.3892/ijmm.2020.4579

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Construction of the drug-target association network. Drug-target networks targeting miRNAs based on (A) the hypermethylated lncRNAs and (B) the hypomethylated lncRNAs were constructed. Drug-target networks targeting mRNAs based on (C) the hypermethylated lncRNAs and (D) the hypomethylated lncRNAs were constructed. Blue circles, yellow circles, red circles and green diamonds represent lncRNAs, miRNAs, mRNAs and small-molecule drugs, respectively. lncRNA, long non-coding RNA; miRNA/miR, microRNA.

Construction of the drug-target association network. Drug-target networks targeting miRNAs based on (A) the hypermethylated lncRNAs and (B) the hypomethylated lncRNAs were constructed. Drug-target networks targeting mRNAs based on (C) the hypermethylated lncRNAs and (D) the hypomethylated lncRNAs were constructed. Blue circles, yellow circles, red circles and green diamonds represent lncRNAs, miRNAs, mRNAs and small-molecule drugs, respectively. lncRNA, long non-coding RNA; miRNA/miR, microRNA.