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. 2020 Apr 8;46(1):211–223. doi: 10.3892/ijmm.2020.4570

Figure 8.

Figure 8

LRP6 reverses the inhibitory effect of miR-346 on the activity, migration and invasion of trophoblast cells. JEG-3 cells were transfected with inhibitor control, miR-346 inhibitor, inhibitor control + mock, and inhibitor + siLRP6, whereas HTR8/SVneo cells were transfected with mimics control, miR-346 mimics, mimics control + mock, and mimics + LRP6. (A and B) CCK-8 assays were performed to detect the cell activity following transfection. Microscopic images and quantitative analysis of (C-F) wound healing and (G-J) Transwell assays in the cells following transfection. The magnification of the images (either x100 or x200) is indicated in the Figure parts, where applicable. **P<0.001; *P<0.05 vs. inhibitor control or mimics control; ##P<0.001; #P<0.05 vs. inhibitor or mimics (n=3).