Table 3:
Univariate Cox Regression Analysis for Overall Survival Over Entire Cohort
| Variable | Hazard Ratio | 95% CI (Lower) | 95% CI (Upper) | p-value |
|---|---|---|---|---|
| Age at Diagnosis | ||||
| <50 | 1 | Reference | ||
| ≥50 | 1.826 | 1.409 | 2.368 | 0.001 |
| Gender | ||||
| Male | 1 | Reference | ||
| Female | 0.989 | 0.799 | 1.223 | 0.918 |
| Ethnicity | ||||
| White | 1 | Reference | ||
| Black | 1.192 | 0.738 | 1.926 | 0.472 |
| Hispanic | 1.039 | 0.781 | 1.384 | 0.791 |
| Asian/Indian | 0.675 | 0.358 | 1.270 | 0.222 |
| Marital Status | ||||
| Married | 1 | Reference | ||
| Unmarried | 1.117 | 0.882 | 1.415 | 0.358 |
| KPS | ||||
| ≥70 | 1 | Reference | ||
| <70 | 3.23 | 2.452 | 4.262 | 0.001 |
| Extent of Surgical Resection | ||||
| Gross Total Resection | 1 | Reference | ||
| Subtotal Resection | 1.698 | 1.182 | 2.440 | 0.004 |
| Biopsy | 2.992 | 2.180 | 4.107 | 0.001 |
| RPA Class | ||||
| III | 1 | Reference | ||
| IV | 2.357 | 1.511 | 3.675 | 0.001 |
| V/VI | 7.815 | 4.816 | 12.681 | 0.001 |
| RT Technique | ||||
| IMRT | 1 | Reference | ||
| 3D CRT | 1.417 | 1.136 | 1.766 | 0.002 |
| 2D | 4.033 | 2.452 | 6.633 | 0.001 |
| RT Total Dose | ||||
| <36 Gy | 4.526 | 3.202 | 6.396 | 0.001 |
| 36–54 Gy | 1.787 | 1.158 | 2.757 | 0.009 |
| >54 Gy | 1 | Reference | ||
| Laterality | ||||
| Unilateral | 1 | Reference | ||
| Bilateral | 1.317 | 0.983 | 1.764 | 0.065 |
| Multicentricity | ||||
| No | 1 | Reference | ||
| Yes | 1.311 | 0.995 | 1.727 | 0.054 |
| IDH-1 Status | ||||
| Negative | 26.362 | 0.296 | 2351.589 | 0.153 |
| Positive | 1 | Reference | ||
| MGMT Status | ||||
| Unmethylated | 1.136 | 0.338 | 3.816 | 0.836 |
| Methylated | 1 | Reference | ||
| Temozolomide | ||||
| Yes | 1 | Reference | ||
| No | 2.285 | 1.451 | 3.598 | 0.001 |