Table 4:
Multivariate Cox Regression Analysis for Overall Survival Over Entire Cohort
| Variable | Hazard Ratio | 95% CI (Lower) | 95% CI (Upper) | p-value |
|---|---|---|---|---|
| Age at Diagnosis | ||||
| <50 | 1 | Reference | ||
| ≥50 | 1.045 | 0.627 | 1.743 | 0.865 |
| Ethnicity | ||||
| White | 1 | Reference | ||
| Black | 0.790 | 0.372 | 1.677 | 0.540 |
| Hispanic | 1.035 | 0.657 | 1.632 | 0.881 |
| Asian/Indian | 0.501 | 0.179 | 1.405 | 0.501 |
| KPS | ||||
| ≥70 | 1 | Reference | ||
| <70 | 3.702 | 1.608 | 8.520 | 0.002 |
| Extent of Surgical Resection | ||||
| Gross Total Resection | 1 | Reference | ||
| Subtotal Resection | 1.532 | 0.992 | 2.366 | 0.054 |
| Biopsy | 2.209 | 1.129 | 4.320 | 0.021 |
| RPA Class | ||||
| III | 1 | Reference | ||
| IV | 3.178 | 1.223 | 8.255 | 0.018 |
| V/VI | 3.499 | 0.979 | 12.508 | 0.054 |
| RT Technique | ||||
| IMRT | 1 | Reference | ||
| 3D CRT | 0.618 | 0.363 | 1.055 | 0.078 |
| 2D | 2.261 | 0.278 | 18.402 | 0.446 |
| RT Total Dose | ||||
| <36 Gy | 3.978 | 1.836 | 8.621 | 0.001 |
| 36–54 Gy | 1.214 | 0.651 | 2.264 | 0.542 |
| >54 Gy | 1 | Reference | ||
| Laterality | ||||
| Unilateral | 1 | Reference | ||
| Bilateral | 1.468 | 0.908 | 2.372 | 0.117 |
| Multicentricity | ||||
| No | 1 | Reference | ||
| Yes | 1.130 | 0.736 | 1.735 | 0.576 |
| Temozolomide | ||||
| Yes | 1 | Reference | ||
| No | 3.908 | 1.526 | 10.008 | 0.004 |