Table 8:
Univariate Cox Regression Analysis for Overall Survival in Patients on Temozolomide
| Variable | Hazard Ratio | 95% CI (Lower) | 95% CI (Upper) | p-value |
|---|---|---|---|---|
| Age at Diagnosis | ||||
| <50 | 1 | Reference | ||
| ≥50 | 1.399 | 0.973 | 2.011 | .070 |
| Gender | ||||
| Male | 1 | Reference | ||
| Female | 0.985 | 0.740 | 1.310 | .917 |
| Ethnicity | ||||
| Hispanic | 1 | Reference | ||
| Black | 1.343 | 0.663 | 2.720 | .413 |
| White | 0.999 | 0.689 | 1.446 | .994 |
| Asian/Indian | 0.599 | 0.234 | 1.533 | .285 |
| Marital Status | ||||
| Married | 1 | Reference | ||
| Unmarried | 1.204 | 0.873 | 1.659 | .258 |
| KPS | ||||
| ≥70 | 1 | Reference | ||
| <70 | 3.680 | 2.551 | 5.308 | <.0001 |
| Extent of Surgical Resection | ||||
| Gross Total Resection | 1 | Reference | ||
| Subtotal Resection | 1.515 | 1.014 | 2.264 | .043 |
| Biopsy | 3.051 | 1.958 | 4.754 | <.0001 |
| RPA Class | ||||
| III | 1 | Reference | ||
| IV | 2.398 | 1.167 | 4.927 | .017 |
| V/VI | 7.314 | 3.391 | 15.774 | <.0001 |
| RT Total Dose | ||||
| <36 Gy | 4.457 | 2.673 | 7.432 | <.0001 |
| 36–54 Gy | 1.750 | 1.015 | 3.016 | .044 |
| >54 Gy | 1 | Reference | ||
| Laterality | ||||
| Unilateral | 1 | Reference | ||
| Bilateral | 1.327 | 0.892 | 1.973 | .162 |
| Multicentricity | ||||
| No | 1 | Reference | ||
| Yes | 1.247 | 0.861 | 1.807 | .243 |
| IDH-1 Status | ||||
| Negative | 26.362 | 0.296 | 2351.589 | .153 |
| Positive | 1 | Reference | ||
| MGMT Status | ||||
| Unmethylated | 1.136 | 0.338 | 3.816 | .836 |
| Methylated | 1 | Reference |