Table 9:
Multivariate Cox Regression Analysis for Overall Survival in Patients on Temozolomide
| Variable | Hazard Ratio | 95% CI (Lower) | 95% CI (Upper) | p-value |
|---|---|---|---|---|
| Age at Diagnosis | ||||
| <50 | 1 | Reference | ||
| ≥50 | 1.036 | 0.630 | 1.705 | .888 |
| KPS | ||||
| ≥70 | 1 | Reference | ||
| <70 | 4.178 | 1.905 | 9.160 | <.0001 |
| Extent of Surgical Resection | ||||
| Gross Total Resection | 1 | Reference | ||
| Subtotal Resection | 1.610 | 1.063 | 2.438 | .024 |
| Biopsy | 2.798 | 1.478 | 5.296 | .002 |
| RPA Class | ||||
| III | 1 | Reference | ||
| IV | 2.396 | 0.956 | 6.003 | .062 |
| V/VI | 2.014 | 0.560 | 7.248 | .284 |
| RT Total Dose | ||||
| <36 Gy | 1.345 | 0.748 | 2.417 | .322 |
| 36–54 Gy | 2.795 | 1.443 | 5.415 | .002 |
| >54 Gy | 1 | Reference |