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. 2020 May 15;16(5):e1008190. doi: 10.1371/journal.ppat.1008190

Fig 8. The role of Cdc45-PCNA interaction at the replication fork.

Fig 8

The active replisome on the leading strand template includes several proteins such as the Cdc45-MCM-GINS complex, DNA pol ε, and PCNA. Here, the heterotetrameric GINS is represented as a single entity. DNA pol ε is depicted with only two subunits: PolE1 (bi-lobed) and PolE2, as the other two subunits have not been identified in trypanosomatids. No Ctf4 has yet been identified in trypanosomatids. The interaction of Cdc45 with PCNA, the sliding clamp processivity factor of the replicative polymerases, may further stabilize the polymerase on the advancing replisome machinery, thus enhancing the efficiency of replication.